JUJU 樹珠 5-Deazaflavin TND1128

In 2019, the World Health Organization (WHO) revised the International Classification of Diseases (ICD) for the first time in 30 years. This revision introduced a new concept: "aging is curable." This was a groundbreaking event for aging researchers worldwide, and drugs to eliminate aging cells are expected to be completed in the near future. 【The key to aging lies in NAD】 Recent studies have shown that the risk of aging-related diseases such as cancer and diabetes increases as the levels of NAD in the body decrease. NAD levels decline with age, and by the late 50s, they are about half of what they were in the 20s. Since the body cannot produce new NAD, it is important to supplement it externally. 【5-Deazaflavin】 The skeletal structure of 5-Deazaflavin is very similar to that of NAD， and it has been confirmed to function in a similar manner. 【5-Deazaflavin, referred to as the next-generation NMN】 NMN needs to be converted into NAD within the body to be effective, whereas 5-Deazaflavin is an NAD-like substance itself and can directly interact with mitochondria and sirtuin genes. 【Jointly developed with Karolinska Institute】 5-Deazaflavin is a compound discovered during research on pharmaceutical compounds for Alzheimer's and dementia, conducted by the world-renowned Karolinska Institute, which has a Nobel Prize in Physiology or Medicine selection committee, in collaboration with a Japanese company. 【Clinical studies on 5-Deazaflavin and NMN (1) - C. elegans Lifespan Extension】 The lifespan curves of humans and C. elegans are quite similar, making the lifespan of C. elegans a good model for studying human longevity. 5-Deazaflavin has been proven to be more effective compared to domestically produced research reagent B-NMN. 【Clinical studies on 5-Deazaflavin and NMN (2) - Mitochondrial Activation Effects】 A study with Kumamoto University confirmed that 5-Deazaflavin activates mitochondria, produces energy (ATP), and stimulates cell metabolism dozens of times more effectively than NMN in a comparative study of mitochondrial activation. (Patent No. 6717989) 【Clinical Study on Hippocampal Cell Development in the Brain】 As the amount of 5-Deazaflavin TND1128 added was increased, it was observed that the axons of neurons in the brain developed more extensively. 【Ensuring the highest quality and safety】 GMP, by the Ministry of Health, Labour and Welfare, ensures fair evaluation of product safety and quality. A "GMP audit" certifies companies meeting standards from raw material reception to shipment. This product, made in an GMP, ISO9001, and FSSC22000 certified facility with Japanese-made 5-deazaflavin, ensures the highest quality and safety. 【Purity testing and radiation analysis】 • Purity test : We ensure that there are no impurities or foreign substances. • Radiation analysis : Prioritizing customer safety, we regularly conduct radiation analysis tests, thoroughly eliminating the risk of radioactive substances. 【Acid-resistant plant-based capsules】 • Acid-resistant : Acid-resistant capsules protect ingredients from stomach acid, ensuring they reach the intestines intact and enhancing absorption efficiency. • Plant-based : Plant-based capsules have a lower allergy risk and are suitable for vegans and vegetarians. They are made from renewable plant resources, ensuring sustainable production. 【Clinical trial】 ◎ blood pressure ◎ neutral fat ◎ Skin / hair ◎ cognitive function ◎ basal metabolism ◎ vision ◎ Reproductive function ◎High blood sugar / obesity According to clinical studies involving 387 customers aged 40 and above to investigate the effects of 5-Deazaflavin. As a result, the studies showed promising outcomes in the prevention and improvement of the aforementioned areas. 【Product Overview】 Reward period : 2 years raw materials : Main Ingredients: Deazaflavin (manufactured in Japan) / Conjugated linoleic acid powder (CLA) Additives: Niacin / soluble dietary fiber / calcium stearate / silicon dioxide Calcium Aluminate / Silicon Dioxide Amount quantity or volume of goods or services : 5 deazaflavin (manufactured in Japan), Contains 50 mg per capsule 60 capsules / Recommended intake: 1 or 2 capsules per day

Enju – Japanese Honeybee Matured Raw Honey

【About “Enju - Honey” - Pure, natural, and patiently aged in the mountains of Japan.】 "Enju" honey, meticulously crafted without heating and filtered twice, offers a smooth, soothing taste that captures the essence of tree flowers in Kikuchi, resulting in a honey with a fruity flavor. The honey produced by Japanese honeybees is highly prized for its rarity, as the amount that can be harvested is limited and seldom found in the market. The whitening of "Enju" honey is a sign of its high glucose content, a testament to its natural purity. A superfood that contains about 150 naturally occurring nutrients that are effective for health and beauty. 【Main Ingredients】 ◎About 10 kinds of vitamins ◎About 22 kinds of amino acids ◎About 27 kinds of minerals ◎About 80 kinds of natural enzymes ◎Polyphenol ◎Glucose Japanese honeybee conservation activities "Enju" honey is made from the flowers of trees nourished by the Kikuchi Water Source, known as one of the premier water sources worldwide. With a population of 740,000, Kumamoto is unique in Japan and rare globally for exclusively using groundwater for its municipal water supply. This abundant water resource has been developed over a long period, facilitated by the permeable terrain formed by eruptions from Mount Aso and the efforts of Kato Kiyomasa, who constructed Kumamoto Castle. The water seeps through layers of earth, slowly flowing and becoming enriched over years. During this process, it acquires a balanced blend of minerals and carbonic acid, transforming into delicious and healthful natural water. From this mineral-rich environment, "Enju" honey is carefully made from the nectar from flowers of various trees, embodying the essence of this exceptional water resource. 【Main Benefits of Representative Trees Growing Naturally in the Honey Harvest Area】 ・Noritsugi (Hydrangea paniculata): Traditionally used to reduce swelling and calm inflammation. ・Himeutsugi (Deutzia crenata): Known for antibacterial and skin-purifying effects. ・Murasaki-natsufuji (Wisteria floribunda): Rich in polyphenols with antioxidant potential. ・Yabukarashi (Cayratia japonica): Called the “king of wild herbs,” valued for digestion and anti-inflammatory support. ・Kanamemochi (Photinia glabra): Folk remedy for coughs and fevers; noted for antibacterial properties. ・Karasuzanshō (Zanthoxylum schinifolium): Refreshing aroma with natural insect-repelling qualities. ・Mukuroji (Sapindus mukorossi): Contains natural saponins for cleansing and detox. ・Tarayō (Ilex latifolia): Traditionally used as a stomachic and antibacterial plant. ・Ume (Japanese plum, Prunus mume): Rich in citric acid; supports recovery from fatigue. ・Uwamizuzakura (Prunus grayana): Medicinal tree known for cough- and phlegm-relieving effects. ・Inu-enju (Japanese pagoda tree): Polyphenol-rich, supporting capillary health and antioxidants. ・Kizuta (Ivy, Hedera rhombea): Moisturizing and anti-inflammatory; noted in skincare use. ・Irohamomiji (Japanese maple, Acer palmatum): Leaves with moisturizing properties, traditionally used in herbal medicine. ・Tochinoki (Horse chestnut, Aesculus turbinata): Contains escin; promotes circulation and reduces swelling. 【Efficacy】　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　 Relieves fatigue, prevents high blood pressure, ischemic heart disease and cerebrovascular disease, prevents arteriosclerosis, prevents aging skin, relieves constipation, prevents infections, maintains health, prevents lifestyle diseases, reduces bad breath, improves immune function, burns fat, anti-aging effect, improves allergy symptoms, reduces blood sugar and cholesterol [Description on product seal] Product name: Japanese Honeybee Matured Raw Honey "Enju" Ingredient name: Pure honey of Japanese honeybee (Kikuchi, Kumamoto) Content quantity: 100g Shelf life: 2 years Storage method: Keep out of direct sunlight and store at room temperature (below 10°C) or refrigerated. Country of origin: Japan Seller: MI Japan GK (Minami Aoyama Ikeda Bldg 7F, 5-13-2 Minami Aoyama, Minato-ku, Tokyo, Japan) Producer: Kazumi Kawakami ( Kikuchi-shi, Kumamoto, Japan) Translated with DeepL.com (free version) 【商品シールの表記】 商品名：日本ミツバチ熟成生はちみつ「延寿」 原材料名：日本ミツバチ純粋はちみつ（熊本県菊池市） 内容量：100g 賞味期限：2年間 保存方法：直射日光を避け常温（１０℃以下）又は冷蔵保存してください 原産国：日本 販売者：合同会社MI Japan（東京都港区南青山5-13-2南青山池田ビル7階） 生産者：川上和美（熊本県菊池市） [Special notes] *Do not give to infants under 1 year of age. Includes a special spoon. Limited to 1,000 units. Includes a number ring (the number cannot be specified). Delivery will be by cool delivery. Avoid direct sunlight and keep at 10°C or below or refrigerated. *Please consume as soon as possible after opening. This product is unheated honey. Please avoid direct sunlight and store at 10°C or below or refrigerated. Please do not boil the product and consume it as is. (Heat may damage the efficacy and taste.) Translated with DeepL.com (free version) 【特記事項】 ※1歳未満の乳児には与えないでください。 ※専用スプーン付 ※販売個数1,000個限定 ※ナンバーリング付き(ナンバーのご指定はできません) ※クール便での配送となります。 ※直射日光を避け、10℃以下又は冷蔵保存でお願いします。 ※開封後は早めにお召し上がりください。 ※本商品は非加熱はちみつです。 ※10℃以下になりますと白く固まります。 ※湯せんはせずに、そのままお召し上がりください。（熱を加えると効能、味が損なわれる可能性があります。）

”Seduce" Signature Deep Moist Lotion (Signature 深层滋润乳液于)

Doctor's cosmetics developed by a biologist at a prestigious university to restore the skin's natural functions. All-in-one (3 functions: lotion, serum, and moisturizer) 【Ingredients and features】 ●Alkalinity Our skin is normally kept in a slightly acidic state. Seduce focuses on this natural skin function. ●Contains EGF (human recombinant oligopeptide-1) Seduce's lotion contains EGF, which helps to keep skin moist and supple. ●Contains acculturated human fat cell supernatant Stem cell culture supernatant is a liquid (supernatant) obtained by culturing hepatocytes in the body and removing the cells from the culture fluid. This supernatant fluid contains ingredients that moisturize and keep the skin healthy, and is expected to be used for anti-aging care(*). *Age-appropriate skin care. ●Contains Canina rosea fruit extract (rose hip) Rosehips are rich in vitamins C, E, and A, which keep the skin healthy and moisturized. The natural rose hips used in Seduce are all organic. We are particular about the extraction method, and each drop is carefully blended. ●No disinfectants, preservatives, etc. Seduce contains no disinfectants, preservatives, synthetic fragrances, petroleum surfactants, alcohol, synthetic colors, phenoxyethanol, mineral oil, or tar-based dyes. 【Product Outline】 Product name: Seduce Signature Deep Moist Lotion Content: 100ml Price: 44,000 JPY (tax included) Ingredients: Water, glycerin, crabapple fruit extract, K hydroxide, loquat leaf extract, Biwa leaf extract, sodium alginate, human fat cell acclimatization culture fluid, human recombinant oligopeptide-1 Made in Japan 博士化妆品由一所著名大学的生物学家研发，旨在恢复皮肤的天然功能。 多功能乳液（三种功能：乳液、精华液和润肤霜） 【成分和特点】 ●碱性。 我们的肌肤通常处于微酸性状态。Seduce 专注于这一天然的皮肤功能。 ●含有 EGF（人类重组寡肽-1） Seduce 润肤露含有 EGF，有助于保持皮肤湿润和柔软。 ●含有经培养的人类脂肪细胞培养液。 干细胞培养上清液是一种液体（上清液），通过在体内培养肝细胞并从培养液中取出细胞而获得。这种上清液含有保湿和保持皮肤健康的成分，有望用于老化护理（*）。 *适合年龄的护肤品。 ●含有卡尼纳巴拉果提取物（玫瑰果）。 玫瑰果富含维生素 C、E 和 A，能保持皮肤健康和滋润。Seduce 使用的天然玫瑰果均为有机产品。萃取方法也经过严格挑选，每一滴都经过精心调配。 ●不含消毒剂、防腐剂等。 不含消毒剂、防腐剂、合成香料、石油表面活性剂、酒精、合成色素、苯氧乙醇、矿物油或焦油基染料。 【产品描述】 产品名称：Signature 深层滋润乳液 容量：100 毫升 价格： ¥44,000（含税） 成分：水、甘油、蟹爪兰果提取物、氢氧化钾、枇杷叶提取物、琵琶叶提取物、海藻酸钠、琵琶叶提取物、海藻酸钠、人类脂肪细胞适应性培养液、人类重组寡肽-1。 日本制造

”Seduce" Signature Deep Moist Lotion 【10-piece set】(Signature 深层滋润乳液于 10 件套)

Doctor's cosmetics developed by a biologist at a prestigious university to restore the skin's natural functions. All-in-one (3 functions: lotion, serum, and moisturizer) 【Ingredients and features】 ●Alkalinity Our skin is normally kept in a slightly acidic state. Seduce focuses on this natural skin function. ●Contains EGF (human recombinant oligopeptide-1) Seduce's lotion contains EGF, which helps to keep skin moist and supple. ●Contains acculturated human fat cell supernatant Stem cell culture supernatant is a liquid (supernatant) obtained by culturing hepatocytes in the body and removing the cells from the culture fluid. This supernatant fluid contains ingredients that moisturize and keep the skin healthy, and is expected to be used for anti-aging care(*). *Age-appropriate skin care. ●Contains Canina rosea fruit extract (rose hip) Rosehips are rich in vitamins C, E, and A, which keep the skin healthy and moisturized. The natural rose hips used in Seduce are all organic. We are particular about the extraction method, and each drop is carefully blended. ●No disinfectants, preservatives, etc. Seduce contains no disinfectants, preservatives, synthetic fragrances, petroleum surfactants, alcohol, synthetic colors, phenoxyethanol, mineral oil, or tar-based dyes. 【Product Outline】 Product name: Seduce Signature Deep Moist Lotion Content: 100ml Price: 44,000 JPY (tax included) → 39,600JPY (10% off) Ingredients: Water, glycerin, crabapple fruit extract, K hydroxide, loquat leaf extract, Biwa leaf extract, sodium alginate, human fat cell acclimatization culture fluid, human recombinant oligopeptide-1 Made in Japan 博士化妆品由一所著名大学的生物学家研发，旨在恢复皮肤的天然功能。 多功能乳液（三种功能：乳液、精华液和润肤霜） 【成分和特点】 ●碱性。 我们的肌肤通常处于微酸性状态。Seduce 专注于这一天然的皮肤功能。 ●含有 EGF（人类重组寡肽-1） Seduce 润肤露含有 EGF，有助于保持皮肤湿润和柔软。 ●含有经培养的人类脂肪细胞培养液。 干细胞培养上清液是一种液体（上清液），通过在体内培养肝细胞并从培养液中取出细胞而获得。这种上清液含有保湿和保持皮肤健康的成分，有望用于老化护理（*）。 *适合年龄的护肤品。 ●含有卡尼纳巴拉果提取物（玫瑰果）。 玫瑰果富含维生素 C、E 和 A，能保持皮肤健康和滋润。Seduce 使用的天然玫瑰果均为有机产品。萃取方法也经过严格挑选，每一滴都经过精心调配。 ●不含消毒剂、防腐剂等。 不含消毒剂、防腐剂、合成香料、石油表面活性剂、酒精、合成色素、苯氧乙醇、矿物油或焦油基染料。 【产品描述】 产品名称：Signature 深层滋润乳液 容量：100 毫升 价格： ¥44,000（含税）→ ¥39,600 (10% 折扣) 成分：水、甘油、蟹爪兰果提取物、氢氧化钾、枇杷叶提取物、琵琶叶提取物、海藻酸钠、琵琶叶提取物、海藻酸钠、人类脂肪细胞适应性培养液、人类重组寡肽-1。 日本制造

”Seduce" Signature Deep Moist Lotion 【30-piece set】(Signature 深层滋润乳液于 30 件套)

Doctor's cosmetics developed by a biologist at a prestigious university to restore the skin's natural functions. 【Ingredients and features】 ●Alkalinity Our skin is normally kept in a slightly acidic state. Seduce focuses on this natural skin function. ●Contains EGF (human recombinant oligopeptide-1) Seduce's lotion contains EGF, which helps to keep skin moist and supple. ●Contains acculturated human fat cell supernatant Stem cell culture supernatant is a liquid (supernatant) obtained by culturing hepatocytes in the body and removing the cells from the culture fluid. This supernatant fluid contains ingredients that moisturize and keep the skin healthy, and is expected to be used for anti-aging care(*). *Age-appropriate skin care. ●Contains Canina rosea fruit extract (rose hip) Rosehips are rich in vitamins C, E, and A, which keep the skin healthy and moisturized. The natural rose hips used in Seduce are all organic. We are particular about the extraction method, and each drop is carefully blended. ●No disinfectants, preservatives, etc. Seduce contains no disinfectants, preservatives, synthetic fragrances, petroleum surfactants, alcohol, synthetic colors, phenoxyethanol, mineral oil, or tar-based dyes. 【Product Outline】 Product name: Seduce Signature Deep Moist Lotion Content: 100ml Price: 44,000 JPY (tax included) → 35,200JPY (20% off) Ingredients: Water, glycerin, crabapple fruit extract, K hydroxide, loquat leaf extract, Biwa leaf extract, sodium alginate, human fat cell acclimatization culture fluid, human recombinant oligopeptide-1 Made in Japan 博士化妆品由一所著名大学的生物学家研发，旨在恢复皮肤的天然功能。 多功能乳液（三种功能：乳液、精华液和润肤霜） 【成分和特点】 ●碱性。 我们的肌肤通常处于微酸性状态。Seduce 专注于这一天然的皮肤功能。 ●含有 EGF（人类重组寡肽-1） Seduce 润肤露含有 EGF，有助于保持皮肤湿润和柔软。 ●含有经培养的人类脂肪细胞培养液。 干细胞培养上清液是一种液体（上清液），通过在体内培养肝细胞并从培养液中取出细胞而获得。这种上清液含有保湿和保持皮肤健康的成分，有望用于老化护理（*）。 *适合年龄的护肤品。 ●含有卡尼纳巴拉果提取物（玫瑰果）。 玫瑰果富含维生素 C、E 和 A，能保持皮肤健康和滋润。Seduce 使用的天然玫瑰果均为有机产品。萃取方法也经过严格挑选，每一滴都经过精心调配。 ●不含消毒剂、防腐剂等。 不含消毒剂、防腐剂、合成香料、石油表面活性剂、酒精、合成色素、苯氧乙醇、矿物油或焦油基染料。 【产品描述】 产品名称：Signature 深层滋润乳液 容量：100 毫升 价格： ¥44,000（含税）→ ¥35,200 (20% 折扣) 成分：水、甘油、蟹爪兰果提取物、氢氧化钾、枇杷叶提取物、琵琶叶提取物、海藻酸钠、琵琶叶提取物、海藻酸钠、人类脂肪细胞适应性培养液、人类重组寡肽-1。 日本制造